Product Description
氧化偶氮甲烷(AOM)是一种甲基化试剂,可在DNA中形成6-O-甲基鸟嘌呤,导致碱基错配,从而诱导组织中肿瘤的形成。
Application Notes
AOM常与致炎剂DSS协同作用,可诱导炎症性肠病(IBD)逐步发展为炎症相关的结直肠肿瘤。AOM/DSS模型能够很好地模拟慢性肠道炎症诱发肿瘤的病理过程,被广泛应用于炎症相关性肿瘤形成机制研究。
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
用于研究结肠癌的发生机制以及化学预防
Specifications
SKU | 0218397180 |
Alternate Names | AOM |
Application Notes | AOM常与致炎剂DSS协同作用,可诱导炎症性肠病(IBD)逐步发展为炎症相关的结直肠肿瘤。AOM/DSS模型能够很好地模拟慢性肠道炎症诱发肿瘤的病理过程,被广泛应用于炎症相关性肿瘤形成机制研究。 |
Base Catalog Number | 183971 |
Biochemical Physiological Actions | Carcinogen that induces O6-methylguanine adducts in DNA leading to G?A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism and of cancer progression and chemoprevention. |
Boiling Point | 97-99 °C |
CAS # | 25843-45-2 |
Density | 0.991 g/mL at 25 °C |
Flash Point | 24 °C/ 75.2 °F |
Hazard Statements | H300-H350 |
Molecular Formula | CH3N=N(←O)CH3 |
Molecular Weight | 74.08 |
Pack Size | 100 mg |
RTECS Number | PA2975000 |
Safety Symbol | GHS06, GHS08 |
Storage | Store a -20 °C |
Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
Certificate of Analysis (COA)
Safety Data Sheets
English (United States)
Brochures
Brochures
Brochures
Brochures
English (United States)
Citations
Case Studies