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氧化偶氮甲烷, Azoxymethan

氧化偶氮甲烷, Azoxymethan
CN¥10,939.56

Key features and details

诱导实验动物结肠癌模型

SKU: 0218397180

Synonyms
AOM
CAS Number:
25843-45-2
Molecular Formula:
CH3N=N(←O)CH3
Molecular Weight:
74.08
MDL Number:
MFCD00126912
Packaging size:
100 mg
Product Description

氧化偶氮甲烷(AOM)是一种甲基化试剂,可在DNA中形成6-O-甲基鸟嘌呤,导致碱基错配,从而诱导组织中肿瘤的形成。

Application Notes

AOM常与致炎剂DSS协同作用,可诱导炎症性肠病(IBD)逐步发展为炎症相关的结直肠肿瘤。AOM/DSS模型能够很好地模拟慢性肠道炎症诱发肿瘤的病理过程,被广泛应用于炎症相关性肿瘤形成机制研究。

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

用于研究结肠癌的发生机制以及化学预防

Specifications
SKU 0218397180
Alternate Names AOM
Application Notes AOM常与致炎剂DSS协同作用,可诱导炎症性肠病(IBD)逐步发展为炎症相关的结直肠肿瘤。AOM/DSS模型能够很好地模拟慢性肠道炎症诱发肿瘤的病理过程,被广泛应用于炎症相关性肿瘤形成机制研究。
Base Catalog Number 183971
Biochemical Physiological Actions Carcinogen that induces O6-methylguanine adducts in DNA leading to G?A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism and of cancer progression and chemoprevention.
Boiling Point 97-99 °C
CAS # 25843-45-2
Density 0.991 g/mL at 25 °C
Flash Point 24 °C/ 75.2 °F
Hazard Statements H300-H350
Molecular Formula CH3N=N(←O)CH3
Molecular Weight 74.08
Pack Size 100 mg
RTECS Number PA2975000
Safety Symbol GHS06, GHS08
Storage Store a -20 °C
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificate of Analysis (COA)

Safety Data Sheets

English (United States)

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Citations
Case Studies