Lithium Chloride
Application Notes
Lithium Chloride is used as an electrolyte for low temperature dry battery cells and as an oxidation catalyst. It is a solubilizer for polyamides and cellulose when used with amide solvents, and is a chlorinating agent for steroid substrates. It has also been utilized in: Large scale plasmid DNA isolation without ultracentrifugation; Protein extraction and protein crystallization; Crystallization of other biological structures, including vitamin B12-RNA aptamer and the L-A virus particle; Inhibits the expression and secretion of insulin-like growth factor-binding protein-1 in H4-II-E cells; Used in the synthesis of beta-substituted alpha-amino acid derivatives; May be used to selectively precipitate RNA.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Chemical Synthesis | DNA & RNA Purification | Protein extraction | Protein crystallization
| SKU | 02194010-CF |
| Alternate Names | Chlorku litu; Chlorure de lithium; Lithiumchlorid |
| Application Notes | Lithium Chloride is used as an electrolyte for low temperature dry battery cells and as an oxidation catalyst. It is a solubilizer for polyamides and cellulose when used with amide solvents, and is a chlorinating agent for steroid substrates. It has also been utilized in: Large scale plasmid DNA isolation without ultracentrifugation; Protein extraction and protein crystallization; Crystallization of other biological structures, including vitamin B12-RNA aptamer and the L-A virus particle; Inhibits the expression and secretion of insulin-like growth factor-binding protein-1 in H4-II-E cells; Used in the synthesis of beta-substituted alpha-amino acid derivatives; May be used to selectively precipitate RNA. |
| Base Catalog Number | 194010 |
| Biochemical Physiological Actions | In developing Xenopus embryos, Lithium Chloride is observed to exert inhibition of glycogen synthase kinase-3β (GSK-3β), yet not reported to be a general inhibitor of other protein kinases. These observations may have implications for Lithium Chloride on cell-fate determination in several organisms including Xenopus and Dictyostelium. Additionally, in transfected Chinese Hamster Ovary cells (CHO) stimulated with angiotension II (Ang II), it was noted that Lithium Chloride enhanced the production of inositol triphosphate. Lithium Chloride may also have anti-viral properties as reported by a study that noted that the compund inhibited pseudorabis virus infection in vitro. In Drosophila, it was observed that in the nervous system, Lithium Chloride may have an effect on amino acid metabolism. Futhermore, in glial primary cell cultures, Lithium Chloride has been noted to provide protection against glutamate excitotoxicity by potentially reducing NR1 mRNA, the major N-methyl-D-aspartate receptor (NMDAR) subunit in the cells. |
| Boiling Point | 2417 to 2480° F at 760 mm Hg (NTP, 1992) |
| CAS # | 7447-41-8 |
| Density | 2.068 at 77° F (NTP, 1992) |
| EC Number | 231-212-3 |
| Format | Powder |
| Grade | Molecular Biology Grade |
| Hazard Statements | H302-H315-H319-H335 |
| Melting Point | 1121° F (NTP, 1992) |
| Molecular Formula | LiCl |
| Molecular Weight | 42.39 g/mol |
| Partition Coefficient | Log P(oct) = -2.66(Lit.) |
| Personal Protective Equipment | Dust mask , Eyeshields, Gloves |
| pH | Aqueous solution: neutral or slightly alkaline |
| Purity | >99% |
| RTECS Number | OJ5950000 |
| Safety Symbol | GHS07 |
| Solubility | Very soluble (NTP, 1992) |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 1 mm Hg at 547 deg C |
![MP COA [194010] lot ID: 1456A](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [194010] lot ID: 1456A")