Dextran
Application Notes
Dextran solutions have been used as plasma extenders. A 6% dextran (MW ~70,000) solution exerts a colloidal osmotic pressure similar to that of plasma proteins. Dextrans with molecular weights greater than 50,000 tend to slowly diffuse across the capillary wall and are slowly metabolized to glucose. Approximately 50% of infused dextran (MW ~70,000) is excreted unchanged in the urine in 24 hours. Dextran can be used to enhance the precipitation and sensitivity of antibody-antigen complexes in immuno-diffusion applications. Dextran (MW ~80,000) was infused into an immunoelectrophoresis gel at a maximum of 80 mg/mL. Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Plasma extender
| SKU | 0520519580 |
| Application Notes | Dextran solutions have been used as plasma extenders. A 6% dextran (MW ~70,000) solution exerts a colloidal osmotic pressure similar to that of plasma proteins. Dextrans with molecular weights greater than 50,000 tend to slowly diffuse across the capillary wall and are slowly metabolized to glucose. Approximately 50% of infused dextran (MW ~70,000) is excreted unchanged in the urine in 24 hours. Dextran can be used to enhance the precipitation and sensitivity of antibody-antigen complexes in immuno-diffusion applications. Dextran (MW ~80,000) was infused into an immunoelectrophoresis gel at a maximum of 80 mg/mL. Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules. |
| Base Catalog Number | 20519580 |
| CAS # | 9004-54-0 |
| EC Number | 232-677-5 |
| Format | Crystalline powder |
| Molecular Weight | 60,000 - 90,000 Da |
| Optical Rotation | +199° (Lit.) |
| Pack Size | 100 g |
| RTECS Number | HH9230000 |
| Sterilization of Solutions | Neutral aqueous dextran solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
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