Product Description
Actinomycin D
Application Notes
Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Selection agent | antineoplastic antibiotic
Specifications
| SKU | 02104658-CF |
| Alternate Names | Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; Meractinomycin; Actinomycin AIV; Actinomycin IV; Actinomycin C1; Actinomycin X1; NSC-3053; Cosmegen |
| Application Notes | Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas. |
| Base Catalog Number | 104658 |
| Beilstein Registry Number | 605235 |
| Biochemical Physiological Actions | Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase. |
| CAS # | 50-76-0 |
| EC Number | 200-063-6 |
| Format | Crystalline powder |
| Hazard Statements | H300 |
| Melting Point | 467 to 469° F (decomposes) (NTP, 1992) |
| Molecular Formula | C62H86N12O16 |
| Molecular Weight | 1255.438 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter |
| Purity | 98% |
| RTECS Number | AU1575000 |
| Safety Symbol | GHS06 |
| Solubility | Soluble at 50° F (NTP, 1992) |
| Source | Streptomyces parvalus |
| Typical Working Concentration | 1 µg/mL |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 0 mm Hg at 25 deg C (est) |
Documents
Certificate of Analysis (COA)
![MP COA [104658] lot ID: 1171F](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [104658] lot ID: 1171F")
Datasheet
Datasheet
Safety Data Sheets
English (United States)