Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.
Application Notes
Actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Actinomycin induces apoptosis and is used as a potent antitumor agent. It is a nucleic acid synthesis inhibitor. It is sed for its antineoplastic properties in the treatment of various malignant neoplasms including Wilm’s tumour, and the sarcomas.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Selection agent | potent antitumor agent | nucleic acid synthesis inhibitor
| SKU | 0219603505 |
| Alternate Names | Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen |
| Application Notes | Actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Actinomycin induces apoptosis and is used as a potent antitumor agent. It is a nucleic acid synthesis inhibitor. It is sed for its antineoplastic properties in the treatment of various malignant neoplasms including Wilm’s tumour, and the sarcomas. |
| Base Catalog Number | 19603505 |
| Beilstein Registry Number | 605235 |
| Biochemical Physiological Actions | An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. |
| CAS # | 50-76-0 |
| EC Number | 200-063-6 |
| Extinction Coefficient | E1% (244nm) = 281 (methanol), E1% (441nm) = 206 (methanol) , EmM (240 nm) = 34.1 (methanol) , EmM (443 nm) = 24.4 (methanol)(Lit.) |
| Hazard Statements | H300 |
| Melting Point | 251-253 °C(Lit.) |
| Molecular Formula | C62H86N12O16 |
| Molecular Weight | 1255.5 |
| Optical Rotation | [α]28D : −315° (c = 0.25% in methanol)(Lit.) |
| Pack Size | 5 mg |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter |
| Purity | 98% |
| RTECS Number | AU1575000 |
| Safety Symbol | GHS06 |
| Solubility | Soluble in methanol (10 mg/mL - clear, orange solution), soluble in DMSO (50 mg/ mL-clear, orange solution), ethanol, chloroform, benzene, ethyl acetate, propylene glycol, chloroform, acetone, water + glycol mixtures. |
| Typical Working Concentration | 1 ug/mL |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
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