Actinomycin D, cell culture reagent

Name: Actinomycin D, cell culture reagent
SKU: 02194525-CF

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Key features and details

Actinomycin D

SKU: 02194525-CF

Synonyms

Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen

CAS Number:

50-76-0

Molecular Formula:

C62H86N12O16

Molecular Weight:

1255.438 g/mol

EC Number:

200-063-6

MDL Number:

MFCD00005033

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Product Description

Actinomycin D

Application Notes

Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic

Specifications

SKU	02194525-CF
Alternate Names	Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen
Application Notes	Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Base Catalog Number	194525
Biochemical Physiological Actions	Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
CAS #	50-76-0
EC Number	200-063-6
Format	Crystalline
Grade	Cell Culture Grade
Hazard Statements	H300
Melting Point	467 to 469Â° F (decomposes) (NTP, 1992)
Molecular Formula	C62H86N12O16
Molecular Weight	1255.438 g/mol
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge
Purity	~98%
Refractive Index	1.656(lit.)
RTECS Number	AU1575000
Safety Symbol	GHS06
Solubility	Soluble at 50Â° F (NTP, 1992)
Typical Working Concentration	cell culture applications at 1µg/mL.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure	0 mm Hg at 25 deg C (est)