Butylated hydroxyanisole

Name: Butylated hydroxyanisole
SKU: 02101162-CF

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Key features and details

Butylated Hydroxytoluene

SKU: 02101162-CF

Synonyms

2,6-Di-tert-Butyl-p-Cresol; BHT; 2,6-Di-t-Butyl-4-MethylPhenol; Butylhydroxytoluene; DBPC; 2,6-Di-tert-butyl-4-methylphenol; 2,6-bis(1,1-Dimethylethyl)-4-methylphenol

CAS Number:

128-37-0

Molecular Formula:

C15H24O

Molecular Weight:

220.356 g/mol

Beilstein Registry Number:

1911640

EC Number:

204-881-4

MDL Number:

MFCD00011644

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Product Description

Butylated Hydroxytoluene

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antioxidant

Specifications

SKU	02101162-CF
Alternate Names	2,6-Di-tert-Butyl-p-Cresol; BHT; 2,6-Di-t-Butyl-4-MethylPhenol; Butylhydroxytoluene; DBPC; 2,6-Di-tert-butyl-4-methylphenol; 2,6-bis(1,1-Dimethylethyl)-4-methylphenol
Base Catalog Number	101162
Beilstein Registry Number	1911640
Biochemical Physiological Actions	Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
Boiling Point	509° F at 760 mm Hg (NTP, 1992)
CAS #	128-37-0
Density	1.048 at 68° F (NTP, 1992)
EC Number	204-881-4
Extinction Coefficient	EmM(278 nm)=1.75-1.83 (in methanol)(Lit.)
Flash Point	260° F (NTP, 1992)
Format	Crystalline powder
Hazard Statements	H302-H315-H319-H411
Melting Point	156 to 160° F (NTP, 1992)
Molecular Formula	C15H24O
Molecular Weight	220.356 g/mol
Personal Protective Equipment	Dust mask, Eyeshields, Gloves
RTECS Number	GO7875000
Safety Symbol	GHS07, GHS09
Solubility	less than 1 mg/mL at 68° F (NTP, 1992)
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Density	7.6 (Air = 1)
Vapor Pressure	0.01 mm Hg (NIOSH, 2016)