Clozapine
Application Notes
Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Blocking of dopamine receptor
| SKU | 02159760-CF |
| Alternate Names | HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801 |
| Application Notes | Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice. |
| Base Catalog Number | 159760 |
| Biochemical Physiological Actions | A typical antipsychotic compound. Selective antagonist for D4- dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors. |
| CAS # | 5786-21-0 |
| EC Number | 227-313-7 |
| Extinction Coefficient | Ethanol: 27.4 (215 nm), 25.8 (230 nm), 16.8 (261 nm), 10.5 (297 nm) (Lit.) |
| Format | Powder |
| Hazard Statements | H301-H341-H361 |
| Melting Point | 183-184 °C |
| Molecular Formula | C18H19N4Cl |
| Molecular Weight | 326.828 g/mol |
| RTECS Number | HP1750000 |
| Safety Symbol | GHS06, GHS08 |
| Solubility | Water Solubility11.8 mg/L |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 1.12X10-8 mm Hg at 25 deg C (est) |
![MP COA [159760] lot ID: 1632A](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [159760] lot ID: 1632A")
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