Concanavalin A, from Canavalia ensiformis seeds (jack beans)

Name: Concanavalin A, from Canavalia ensiformis seeds (jack beans)
SKU: 02150710-CF

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Key features and details

Concanavalin A

SKU: 02150710-CF

Synonyms

Con A

CAS Number:

11028-71-0

Molecular Weight:

6312.315 g/mol

EC Number:

234-258-2

MDL Number:

MFCD00071069

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Product Description

Concanavalin A

Application Notes

Lectin are used in a wide variety of applications in vitro, including: blood grouping and erythrocyte polyagglutination studies, Mitogenic stimulation of lymphocytes, Lymphocyte subpopulation studies, Fractionation of cells and other particles, Histochemical studies of normal and pathological conditions. Con-A has been used to elucidate structural changes in the membrane surface of transformed cells. Con-A conjugates of antitumor drugs have been used in drug delivery systems in cultured cells.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cell Biology | Cell Signaling

Specifications

SKU	02150710-CF
Alternate Names	Con A
Application Notes	Lectin are used in a wide variety of applications in vitro, including: blood grouping and erythrocyte polyagglutination studies, Mitogenic stimulation of lymphocytes, Lymphocyte subpopulation studies, Fractionation of cells and other particles, Histochemical studies of normal and pathological conditions. Con-A has been used to elucidate structural changes in the membrane surface of transformed cells. Con-A conjugates of antitumor drugs have been used in drug delivery systems in cultured cells.
Base Catalog Number	150710
Biochemical Physiological Actions	Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6. Con-A binds specifically to mannosyl and glucosyl residues of polysaccharides and glycoproteins. Unmodified hydroxyl groups at the C3, C4 and C6 positions of D-glucopyranosyl or D-mannopyranosyl rings may be essential for binding. Each subunit of Con-A contains one calcium ion and one manganese ion. Removal of these cations by dialysis under acidic conditions abolishes the carbohydrate-binding activity.
CAS #	11028-71-0
EC Number	234-258-2
Extinction Coefficient	280nm = 11.4 (0.1 M NaCl)(Lit.)
Format	Powder
Hazard Statements	H317-H334-H361
Isoelectric Point	4.5, 4.7, 5.0-5.1, and 5.4-5.5 (several isoforms)(Lit.)
Molecular Weight	6312.315 g/mol
Personal Protective Equipment	Dust mask, Eyeshields, Faceshields, Gloves
RTECS Number	GK6890000
Safety Symbol	GHS08
Source	Canavalia ensiformis seeds (jack beans)
Specificity	Carbohydrate Specificity: a-Mannose; a-Glucose; Branched Mannose.
Typical Working Concentration	Reconstitution: Reconstitute with buffer to a final concentration of 1 mg/mL.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.