Etoposide

Name: Etoposide
SKU: 02193918-CF

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Key features and details

Etoposide

SKU: 02193918-CF

Synonyms

EPA; Demethyl-epiodophyllotoxin ethylidene glucoside; Vepesid; EPEG; VP-16; VP-16213; NK 171; NSC-141540; 4'-Demethylepipodophyllotoxin; 9-(4,6-O-Ethylidene-b-D-Glucopyranoside)

CAS Number:

33419-42-0

Molecular Formula:

C29H32O13

Molecular Weight:

588.562 g/mol

EC Number:

251-509-1

MDL Number:

MFCD00869325

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Product Description

Etoposide

Application Notes

Etoposide inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53−/−) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Topoisomerase inhibitor

Specifications

SKU	02193918-CF
Alternate Names	EPA; Demethyl-epiodophyllotoxin ethylidene glucoside; Vepesid; EPEG; VP-16; VP-16213; NK 171; NSC-141540; 4'-Demethylepipodophyllotoxin; 9-(4,6-O-Ethylidene-b-D-Glucopyranoside)
Application Notes	Etoposide inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53−/−) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.
Base Catalog Number	193918
Biochemical Physiological Actions	Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.
CAS #	33419-42-0
EC Number	251-509-1
Format	Powder
Hazard Statements	H302-H350
Melting Point	236-251 Â°C
Molecular Formula	C29H32O13
Molecular Weight	588.562 g/mol
Personal Protective Equipment	Eyeshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
pKa	9.8 (Lit.)
RTECS Number	KC0190000
Safety Symbol	GHS07, GHS08
Solubility	<h5 class="minor-section-title">Water Solubility</h5>Sparingly soluble
Storage	BIOCHEMICALS
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance	λmax (methanol)
Vapor Pressure	5.4X10-23 mm Hg at 25 deg C /Estimated/