A bactericidal aminoglycoside antibiotic predominantly active against gram-negative bacteria. It disrupts protein synthesis at the 30S ribosome. Used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. Approximately 600 µg gentamycin per mg.
Application Notes
Gentamicin sulfate is a broad spectrum antibiotic. It inhibits the growth of a wide variety of Gram-positive and Gram-negative microorganisms, including strains resistant to tetracycline, chloramphenicol, kanamycin, and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus, and Streptococcus. Gentamicin sulfate inhibits bacterial protein biosynthesis by binding to the 30S subunit of the ribosome.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
| SKU | 02194530-CF |
| Alternate Names | Garamycin; Genoptic; GM Sulfate;Gentiomycin C |
| Application Notes | Gentamicin sulfate is a broad spectrum antibiotic. It inhibits the growth of a wide variety of Gram-positive and Gram-negative microorganisms, including strains resistant to tetracycline, chloramphenicol, kanamycin, and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus, and Streptococcus. Gentamicin sulfate inhibits bacterial protein biosynthesis by binding to the 30S subunit of the ribosome. |
| Base Catalog Number | 194530 |
| Biochemical Physiological Actions | Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria. |
| CAS # | 1405-41-0 |
| EC Number | 215-778-9 |
| Format | Powder |
| Grade | Cell Culture Grade |
| Hazard Statements | H317-H334 |
| Molecular Formula | C21H43N5O7-H2SO4 |
| Molecular Weight | 575.70 |
| Optical Rotation | +116° |
| Personal Protective Equipment | Dust mask type , Eyeshields, Faceshields, Gloves |
| Potency | >590 µg/mg |
| RTECS Number | LY2625000 |
| Safety Symbol | GHS08 |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [194530] lot ID: 1172A](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [194530] lot ID: 1172A")