Gossypol-Acetic Acid
Application Notes
In a study on the apoptotic effect of gossypol on human lymphocytes, gossypol was used at 20-50 mM to induce apoptosis in human lymphocytes without causing necrosis through cytotoxic effects. The combined use of steroid hormones (methyltestosterone and ethinyl estradiol) and gossypol (low dose) in an antifertility study in rats showed that the steroid hormone made the procedure of spermatogenesis slower and low dose gossypol caused all sperm to lose their activity in the epididymis. Both affect the process of spermatogenesis from different endpoints and successfully induce infertility in the short term. A low dose of gossypol not only executes antifertility function in the epididymis, but also affects the quality of spermatozoal production in testis by impacting the procedures of both acrosomal formation and spermatozoal elongation. This assists in maintaining long term infertility. Gossypol, as a PAF antagonist/inhibitor, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4, leukotriene D4, and PAF-acether. It was suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung. Inhibits the autolytic conversion of pepsinogen to pepsin.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
PAF antagonist/inhibitor
| SKU | 02195211-CF |
| Alternate Names | (±)-Gossypol-acetic acid; (+/–) Gossypol acetate |
| Application Notes | In a study on the apoptotic effect of gossypol on human lymphocytes, gossypol was used at 20-50 mM to induce apoptosis in human lymphocytes without causing necrosis through cytotoxic effects. The combined use of steroid hormones (methyltestosterone and ethinyl estradiol) and gossypol (low dose) in an antifertility study in rats showed that the steroid hormone made the procedure of spermatogenesis slower and low dose gossypol caused all sperm to lose their activity in the epididymis. Both affect the process of spermatogenesis from different endpoints and successfully induce infertility in the short term. A low dose of gossypol not only executes antifertility function in the epididymis, but also affects the quality of spermatozoal production in testis by impacting the procedures of both acrosomal formation and spermatozoal elongation. This assists in maintaining long term infertility. Gossypol, as a PAF antagonist/inhibitor, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4, leukotriene D4, and PAF-acether. It was suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung. Inhibits the autolytic conversion of pepsinogen to pepsin. |
| Base Catalog Number | 195211 |
| Biochemical Physiological Actions | The toxicity of gossypol is shown against the reproductive system, heart, liver, and membranes. The compound exhibits both pro- and anti-oxidant behavior. Electron transfer (ET) functionalities, present in gossypol and its metabolites, comprise conjugated dicarbonyl, a quinone derivative, Schiff bases, and metal complexes. The parent possesses a reduction potential favorable for in vivo ET. Considerable evidence points to oxidative stress, formation of a reactive oxygen species, and DNA scission, characteristics of redox cycling by ET in biosystems, as mechanism of action for gossypol. Reported to inhibit the autolytic conversion of pepsinogen to pepsin. |
| CAS # | 12542-36-8 |
| Format | Powder |
| Hazard Statements | H302-H351 |
| Molecular Formula | C30H30O8·C2H4O2 |
| Molecular Weight | 578.614 g/mol |
| Personal Protective Equipment | Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter |
| RTECS Number | MD7360000 |
| Safety Symbol | GHS07, GHS08 |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [195211] lot ID: 2548J](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [195211] lot ID: 2548J")