Ionomycin
Application Notes
Ionomycin is a useful tool for increasing intracellular Ca2+ concentration . It is also used to equilibrate intracellular and extracellular calcium ion levels for in situ calibrations of fluorescent indicators. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Studies of Ca2+ transport | Equilibrate intracellular and extracellular calcium ion levels | Selective calcium ionophore
| SKU | 0215961101 |
| Application Notes | Ionomycin is a useful tool for increasing intracellular Ca2+ concentration . It is also used to equilibrate intracellular and extracellular calcium ion levels for in situ calibrations of fluorescent indicators. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. |
| Base Catalog Number | 15961101 |
| Beilstein Registry Number | 3642126 |
| Biochemical Physiological Actions | Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination and inhibits adrenal bovine TREK-1 channels. |
| CAS # | 56092-81-0 |
| Format | Gel |
| Hazard Statements | H302 |
| Molecular Weight | 709.018 g/mol |
| Pack Size | 1 mg |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| Purity | ≥90% |
| RTECS Number | NO0600000 |
| Safety Symbol | GHS07 |
| Source | Streptomyces conglobatus |
| Typical Working Concentration | Ionomycin is used at concentration of 3nM and 2-4µM (whole cells). |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
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