From Streptomyces kanamycetikus. An aminoglycoside bacteriocidal antibiotic that acts against gram-positive and gram-negative bacteria. Inhibits protein biosynthesis by causing a misreading of the 70s-ribosome. Useful in plant cell culture for selection of the kanamycin-resistance gene.
Application Notes
Kanamycin Sulfate used in biotechnology applications to inhibit protein synthesis. Active against many strains of Gram-negative bacteria and Gram positive Staphylococcus aureus and S. epidermis. Some strains of Mycobacterium are sensitive. Most active in alkaline solution. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotics
| SKU | 02194531-CF |
| Alternate Names | Kanamycin A; Kanamycin sulfate salt |
| Application Notes | Kanamycin Sulfate used in biotechnology applications to inhibit protein synthesis. Active against many strains of Gram-negative bacteria and Gram positive Staphylococcus aureus and S. epidermis. Some strains of Mycobacterium are sensitive. Most active in alkaline solution. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. |
| Base Catalog Number | 194531 |
| Biochemical Physiological Actions | Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma. |
| CAS # | 25389-94-0 |
| EC Number | 246-933-9 |
| Format | Powder |
| Grade | Cell Culture Grade |
| Hazard Statements | H360 |
| Molecular Formula | C18H36N4O11 |
| Molecular Weight | 582.60 |
| Personal Protective Equipment | Eyeshields, Gloves, Respirator filter |
| Potency | ~ 735 ug/mg |
| RTECS Number | NZ3225030 |
| Safety Symbol | GHS08 |
| Typical Working Concentration | 100 mg/L |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [02194531-CF] lot ID: YC11019](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [02194531-CF] lot ID: YC11019")