Camptothecin, ≥97%

Name: Camptothecin, ≥97%
SKU: 02159732-CF

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Key features and details

Camptothecin

SKU: 02159732-CF

Synonyms

Camptothecine; (S)-(+)-Camptothecin

CAS Number:

7689-03-4

Molecular Formula:

C20H16N2O4

Beilstein Registry Number:

631069

MDL Number:

MFCD00081076

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Product Description

Camptothecin

Application Notes

Camptothecin used to study transbilayer phospholipid movements by inducing apoptosis in EBV transformed B lymphocytes from ABCA1-Deficient Cells. Although most noted for its anticancer activity, Camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Binds to and stabilizes the topoisomerase-DNA covalent complex

Specifications

SKU	02159732-CF
Alternate Names	Camptothecine; (S)-(+)-Camptothecin
Application Notes	Camptothecin used to study transbilayer phospholipid movements by inducing apoptosis in EBV transformed B lymphocytes from ABCA1-Deficient Cells. Although most noted for its anticancer activity, Camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.
Base Catalog Number	159732
Beilstein Registry Number	631069
Biochemical Physiological Actions	(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
CAS #	7689-03-4
Extinction Coefficient	EmM = 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm) (Lit.)
Format	Solid
Hazard Statements	H302
Molecular Formula	C20H16N2O4
Optical Rotation	-139.5 ° (10 mg/mL, pyridine, 25 °C) (Lit.)
Personal Protective Equipment	Eyeshields, Faceshields, Gloves, Respirator cartridges
Purity	≥97%
Refractive Index	n20D 1.75 (Lit.)
RTECS Number	UQ0492000
Safety Symbol	GHS07
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.