Product Description
Doxorubicin Hydrochloride
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Chemotherapeutic agent
Specifications
SKU | 02159101-CF |
Alternate Names | Adriamycin; 14-Hydroxydaunomycin; HCl; DOX; Hydroxydaunorubicin hydrochloride; 14-Hydroxydaunomycin hydrochloride; 10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl) hydrochloride; Doxorubicin |
Base Catalog Number | 159101 |
Beilstein Registry Number | 4229251 |
Biochemical Physiological Actions | Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis. Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. |
CAS # | 25316-40-9 |
EC Number | 246-818-3 |
Format | Powder |
Hazard Statements | H302-H350 |
Melting Point | 399 to 401° F (Decomposes) (NTP, 1992) |
Molecular Formula | C27H29NO11·HCl |
Molecular Weight | 579.983 g/mol |
Personal Protective Equipment | Eyeshields, Full-face respirator, Gloves, Multi-purpose combination respirator cartridge, Respirator filter |
Purity | ≥95% |
RTECS Number | QI9295900 |
Safety Symbol | GHS07, GHS08 |
Solubility | Soluble (NTP, 1992) |
Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Vapor Pressure | 2.5X10-23 at 25 deg C (est) |
Documents
Certificate of Analysis (COA)
Datasheet
Datasheet
Safety Data Sheets
English (United States)