Mitomycin C
Application Notes
Mitomycin C is the most widely used as Mitomycin antibiotics because it is the least toxic and with the most potent antitumor activity. It has extraordinarily strong activity against Ehrlich ascites tumor cells.It also possesses strong bactericidal action against Gram-positive and Gram-negative organisms and acid-fact bacilli. Mitomycin C is used to generate mitotically inactive feeder cells used in cell culture systems, such as mitotically inactive fibroblast used in embryonic stem cell (ESC) systems.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Generate mitotically inactive feeder cells
| SKU | 0219453202 |
| Alternate Names | Ametycin; 7-Amino-9-a-methoxymitosane; Mit-C; Mitocin-C; Mitomycinum; Mutamycin; Azirizino[2', 3': 3,4] pyrrolo [1,2-a] indole 4,7-dione-6-amino-1,1a, 2, 8, 8a, 8b-hexahydro- 8- (hydroxymethyl) 8a-methoxy-5-methyl carbamate |
| Application Notes | Mitomycin C is the most widely used as Mitomycin antibiotics because it is the least toxic and with the most potent antitumor activity. It has extraordinarily strong activity against Ehrlich ascites tumor cells.It also possesses strong bactericidal action against Gram-positive and Gram-negative organisms and acid-fact bacilli. Mitomycin C is used to generate mitotically inactive feeder cells used in cell culture systems, such as mitotically inactive fibroblast used in embryonic stem cell (ESC) systems. |
| Base Catalog Number | 19453202 |
| Beilstein Registry Number | 7231816 |
| Biochemical Physiological Actions | Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5'-CpG-3'. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria. |
| Boiling Point | 534 °C |
| CAS # | 50-07-7 |
| EC Number | 200-008-6 |
| Grade | Cell Culture Grade |
| Hazard Statements | H302-H351 |
| Melting Point | Above 680° F (EPA, 1998) |
| Molecular Formula | C15H18N4O5 |
| Molecular Weight | 334.332 g/mol |
| Pack Size | 2 mg |
| RTECS Number | CN0700000 |
| Safety Symbol | GHS07, GHS08 |
| Solubility | Soluble (NTP, 1992) |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![DS [02194532]](https://www.mpbiochina.com/static/version1715758459/frontend/Mpbio/default/en_US/images/document.png "DS [02194532]")