Wortmannin

Name: Wortmannin
SKU: 02195690-CF

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Key features and details

Wortmannin

SKU: 02195690-CF

Synonyms

[1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420

CAS Number:

19545-26-7

Molecular Formula:

C23H24O8

Molecular Weight:

428.437 g/mol

Beilstein Registry Number:

67676

MDL Number:

MFCD00133927

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Product Description

Wortmannin

Application Notes

Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Phosphatidylinositol 3-kinase (PI3-K) inhibitor

Specifications

SKU	02195690-CF
Alternate Names	[1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420
Application Notes	Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.
Base Catalog Number	195690
Beilstein Registry Number	67676
Biochemical Physiological Actions	Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
CAS #	19545-26-7
Format	Powder
Hazard Statements	H300-H310-H330
Molecular Formula	C23H24O8
Molecular Weight	428.437 g/mol
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS Number	CB9641000
Safety Symbol	GHS06
Source	Penicillium wortmannii
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.