A polyene antifungal effective against molds, fungi and yeast contamination. It binds to ergosterol and creates nystatin/ergosterol based ion channels in lipid bilayers causing K+ leakage that results in fungal cell death.
Application Notes
Nystatin is a polyene antibiotic. Its uses include preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in TLR2-expressing THP1 cells.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SKU | 02194534-CF |
Alternate Names | Mycostatin;Fungicidin |
Application Notes | Nystatin is a polyene antibiotic. Its uses include preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in TLR2-expressing THP1 cells. |
Base Catalog Number | 194534 |
Biochemical Physiological Actions | Mode of Action: Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.Antimicrobial spectrum: Neomycin acts against fungi, yeasts and molds. |
CAS # | 1400-61-9 |
EC Number | 215-749-0 |
Format | Powder |
Grade | Cell Culture Grade |
Molecular Formula | C47H75NO17 |
Molecular Weight | 926.10 |
Personal Protective Equipment | Eyeshields, Gloves, Respirator filter |
RTECS Number | RF5950000 |
Specific Activity | >5000 u/mg |
Typical Working Concentration | 50 mg/L for yeasts and fungi. |
Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
UV Visible Absorbance | 290, 305, 320 ± 2 nm( λ max (ethanol)) |