An aminoglycoside antibiotic effective against gram-negative bacteria. Like neomycin, it inhibits protein synthesis by binding to 16s-ribosomal RNA. Useful in studies of cytosine-cytosine (CC) mismatch containing RNAs.
Application Notes
Paromomycin sulfate salt has been used as a• reference compound in antileishmanial activity• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SKU | 02194535-CF |
Application Notes | Paromomycin sulfate salt has been used as a• reference compound in antileishmanial activity• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex |
Base Catalog Number | 194535 |
Beilstein Registry Number | 5715182 |
Biochemical Physiological Actions | Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death. |
CAS # | 1263-89-4 |
EC Number | 215-031-7 |
Format | Powder |
Grade | Cell Culture Grade |
Molecular Formula | C23H45N5O14-H2SO4 |
Molecular Weight | 713.70 |
Potency | >675 µg/mg |
Purity | ≥97% |
RTECS Number | WK2320000 |
Typical Working Concentration | Paromomycin sulfate is recommended for use in cell culture applications at 100 mg/L. |
Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |