A bactericidal antibiotic drug of the rifamycin group. It specifically inhibits DNA-dependent bacterial RNA Polymerase. Mammalian RNA polymerase is not affected so it is useful in plant cell culture work. It is effective against mycobacteria. Also an inhibitor of chloroplast RNA polymerase and may be used to study chloroplast-level DNA transcription in plants.
Application Notes
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Inhibitor of transcription initiation | Antipruritic agent
| SKU | 02195490-CF |
| Alternate Names | Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin |
| Application Notes | Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis. |
| Base Catalog Number | 195490 |
| Beilstein Registry Number | 5723476 |
| Biochemical Physiological Actions | Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. It Inhibits the assembly of DNA and protein into mature virus particles. |
| CAS # | 13292-46-1 |
| EC Number | 236-312-0 |
| Extinction Coefficient | EmM (max absorbance, phosphate buffer,pH 7.38): 33.20 (237 nm); 32.10 (255 nm); 27.00 (334 nm);15.40 (475 nm)(Lit.) |
| Format | Powder |
| Hazard Statements | H302-H315-H319-H335 |
| Isoelectric Point | 4.8(in water)(Lit.) |
| Melting Point | 183 °C |
| Molecular Formula | C43H58N4O12 |
| Molecular Weight | 822.90 |
| Optical Rotation | [α]D25°=+10.6° (c=0.5% in CDCl3)(Lit.) |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| pKa | pKa (in water):1.7 (4-hydroxyl group), 7.9 (4-piperazine nitrogen); in methylcellosolve-water (4:1): 3.6 (4-hydroxyl group), 6.7 (3-piperazine nitrogen)(Lit.) |
| RTECS Number | VJ7000000 |
| Safety Symbol | GHS07 |
| Solubility | <h5 class="minor-section-title">Water Solubility</h5>1400 mg/L (at 25 °C) |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| UV Visible Absorbance | λ max (methanol): 237 - 239, 334 - 338, 475 - 479 nm |
| Vapor Pressure | 3.1X10-34 mm Hg at 25 deg C /Estimated/ |
![MP COA [195490] lot ID: 1544J](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "MP COA [195490] lot ID: 1544J")