Poly-L-lysine hydrochloride

Name: Poly-L-lysine hydrochloride
SKU: 02152690-CF

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Key features and details

Poly-L-lysine is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates.

SKU: 02152690-CF

Synonyms

PLL HCl

CAS Number:

26124-78-7

MDL Number:

MFCD00081870

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Product Description

Poly-L-Lysine Hydrochloride

Application Notes

Poly-L-lysine is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates. Poly-L-lysine enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When adsorbed to the culture surface, poly-L-lysine increases the number of positively charged sites available for cell binding. Polymers of both D- and L-lysine are used to coat solid surfaces. Poly-L-lysine has been reported to improve the protein coating of ELISA plates. Other uses for poly-lysine have been reported as follow: 1.Conjugation to methotrexate for increased drug transport. 2.Microencapsulation of islets. 3.Use in simple reproducible procedure for chromosomal preparations from a variety of tissues. 4.Immobilation of living cells in biocompatible semipermeable microcapsules. 5.Poly-L-Lysine In the preparation of polycationic beads. 6.Conjugation to albumin and horseradish peroxidase to enhance cellular uptake.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cellular attachment factor in culture applications

Specifications

SKU	02152690-CF
Alternate Names	PLL HCl
Application Notes	Poly-L-lysine is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates. Poly-L-lysine enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When adsorbed to the culture surface, poly-L-lysine increases the number of positively charged sites available for cell binding. Polymers of both D- and L-lysine are used to coat solid surfaces. Poly-L-lysine has been reported to improve the protein coating of ELISA plates. Other uses for poly-lysine have been reported as follow: 1.Conjugation to methotrexate for increased drug transport. 2.Microencapsulation of islets. 3.Use in simple reproducible procedure for chromosomal preparations from a variety of tissues. 4.Immobilation of living cells in biocompatible semipermeable microcapsules. 5.Poly-L-Lysine In the preparation of polycationic beads. 6.Conjugation to albumin and horseradish peroxidase to enhance cellular uptake.
Base Catalog Number	152690
CAS #	26124-78-7
Format	Powder
Personal Protective Equipment	Eyeshields, Gloves, respirator filter
Typical Working Concentration	Typically, the effective coating solution concentration for culture dishes will be 0.3 to 0.5% and for histology slides at 0.1%.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.