Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis.
Application Notes
Orotic acid (OA) may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT)
| SKU | 0215600025 |
| Alternate Names | 6-Carboxy-2,4-dihydroxy- pyrimidine; Uracil-6-carboxylic acid |
| Application Notes | Orotic acid (OA) may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis. |
| Base Catalog Number | 15600025 |
| CAS # | 24598-73-0 |
| EC Number | 246-341-0 |
| Molecular Formula | C5H3KN2O4 |
| Molecular Weight | 194.2 |
| Pack Size | 25 g |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| RTECS Number | RM3201500 |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |