Oxytetracycline is a tetracycline analog isolated from the actinomycete streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae.
Application Notes
Oxytetracycline hydrochloride is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells1 and antibiotic susceptibilities of Mycopasma bovis isolates.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
| SKU | 0215014510 |
| Alternate Names | Alamycin; 5-Hydroxytetracycline hydrochloride; Bisolvomycin; Hydrocyclin; NSC 9169; Teramycin hydrochloride; Tetramine; Tetran hydrochloride |
| Application Notes | Oxytetracycline hydrochloride is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells1 and antibiotic susceptibilities of Mycopasma bovis isolates. |
| Base Catalog Number | 15014510 |
| Beilstein Registry Number | 3853107 |
| Biochemical Physiological Actions | Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane. |
| CAS # | 2058-46-0 |
| EC Number | 218-161-2 |
| Melting Point | 165 °C (dec.) (Lit.) |
| Molecular Formula | C22H24N2O9 • HCl |
| Molecular Weight | 496.9 |
| Pack Size | 10 g |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| RTECS Number | QI8225000 |
| Solubility | Very soluble in water (1 g/mL).Soluble in absolute ethanol. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![DS [02150145]](https://www.mpbiochina.com/static/version1714032662/frontend/Mpbio/default/en_US/images/document.png "DS [02150145]")