Streptomycin Sulfate is an aminoglucoside antibiotic in which streptidine is linked glycosidically to the disaccharide streptobiosamine. It is most active in a slightly alkaline medium. Inhibits initiation and causes misreading of rRNA in protein synthesis. Effective against gram-negative and gram-positive bacteria. About one-third of streptomycin in the circulation is bound to plasma proteins. About 30-90% of a dose is excreted unchanged in the urine in 24 hours.
Application Notes
Streptomycin, in combination with penicillin, is used in a standard antibiotic cocktail to prevent bacterial infection in cell culture. Streptomycin also is used as a pesticide, to combat the growth of bacteria, fungi, and algae. Streptomycin controls bacterial and fungal diseases of certain fruit, vegetables, seed, and ornamental crops, and it controls algae in ornamental ponds and aquaria.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Pesticide | Cell culture | Treatment of Tuberculosis, Plague
| SKU | 0219454105 |
| Alternate Names | Streptomycin Sesquisulfate; O-2-Deoxy-2-(methylamino)-a-L- glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl- (1->4)- N,N'- bis(aminoiminomethyl)-D-streptamine; Streptomycin A |
| Application Notes | Streptomycin, in combination with penicillin, is used in a standard antibiotic cocktail to prevent bacterial infection in cell culture. Streptomycin also is used as a pesticide, to combat the growth of bacteria, fungi, and algae. Streptomycin controls bacterial and fungal diseases of certain fruit, vegetables, seed, and ornamental crops, and it controls algae in ornamental ponds and aquaria. |
| Base Catalog Number | 19454105 |
| Beilstein Registry Number | 3894995 |
| Biochemical Physiological Actions | Mode of Action: Inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome and casues miscoding: Binds to S12 protein of 30S ribosomal subunit causing the misreading or the inhibition of initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Inactivation: Streptomycin is inactivated by acids, alkalis, oxidizing and reducing agents, urea and other carbonyl-containing compounds, as well as by cysteine and other sulfhydryl-containing substances. Loss in potency was reported. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. |
| CAS # | 3810-74-0 |
| EC Number | 223-286-0 |
| Grade | Cell Culture Grade |
| Hazard Statements | H302-H361 |
| Molecular Formula | 2C21H39N7O12 • 3H2SO4 |
| Molecular Weight | 1457.4 |
| Pack Size | 5 g |
| Personal Protective Equipment | Dust mask, Eyeshields, Faceshields, Gloves |
| RTECS Number | WK4990000 |
| Safety Symbol | GHS07, GHS08 |
| Solubility | Soluble in aqueous solution (4% aq soln) (1 g/10 mL water - clear,colorless solution). |
| Specific Activity | ≥650 u/mg |
| Typical Working Concentration | Typically used at a concentration of 50-100 mg/liter. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
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