Tetramisole is an alkaline phosphatase inhibitor. It is a racemic mixture of (+) and (-) isomers. The (-) isomer (levamisole) accounts for most of the biological activity of tetramisole.
Application Notes
Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited. Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors. In addition to its use in enzyme and protein phosphorylation studies, tetramisole has been used to study membrane, tissue and animal systems.Tetramisole is an antihelminthic agent used in veterinary applications to treat helminth or worm infections.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Used in enzyme and protein phosphorylation studies
| SKU | 0215211910 |
| Alternate Names | DL-2,3,5,6-Tetrahydro-6-phenylimidazo-[2,1-b]-thiazole hydrochloride; (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride |
| Application Notes | Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited. Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors. In addition to its use in enzyme and protein phosphorylation studies, tetramisole has been used to study membrane, tissue and animal systems.Tetramisole is an antihelminthic agent used in veterinary applications to treat helminth or worm infections. |
| Base Catalog Number | 15211910 |
| Beilstein Registry Number | 4358989 |
| CAS # | 5086-74-8 |
| EC Number | 225-799-5 |
| Hazard Statements | H302-H315-H319-H335 |
| Melting Point | 266 - 267 °C (Lit.) |
| Molecular Formula | C11H12N2S*HCl |
| Molecular Weight | 240.76 |
| Pack Size | 10 g |
| Personal Protective Equipment | Dust mask, Eyeshields, Faceshields, Gloves |
| pKa | 8.0 (Lit.) |
| RTECS Number | NJ5950000 |
| Safety Symbol | GHS07 |
| Solubility | Soluble in water (50 mg/mL - clear colorless soltion). |
| Typical Working Concentration | Tetramisole has been used to inhibit alkaline phosphatase in the effective range of 0.4 – 2 mM. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |